ИМХО - интересно: медицинские ссылки.

[pavelf]

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[Dr.Vad]

Patients orally took capsules containing either vitamin K2 (menaquinone 7), 180 μg, or a similar-looking placebo every day for 8 weeks.

Of the 199 enrolled individuals, 108 (54.3%) were female, and the mean (SD) age was 72.3 (5.5) years. A total of 103 patients (51.8%) were randomly assigned to receive vitamin K2 and 96 (48.2%) were assigned to placebo.

The mean (SD) baseline weekly frequency of cramps was comparable in both the vitamin K2 group (2.60 [0.81]) and the placebo group (2.71 [0.80]).

During the 8-week intervention, the vitamin K2 group experienced a reduction in the mean (SD) weekly frequency of cramps to 0.96 (1.41). Meanwhile, the placebo group maintained mean (SD) weekly frequency of cramps at 3.63 (2.20). The between-group difference was statistically significant (difference, −2.67; 95% CI, −2.86 to −2.49; P < .001).

The vitamin K2 group had a more significant mean (SD) reduction in NLC severity (−2.55 [2.12] points) compared with the placebo group (−1.24 [1.16] points).

The vitamin K2 group exhibited a more pronounced mean (SD) decrease in the duration of NLCs (−0.90 [0.88] minutes) than the placebo group (−0.32 [0.78] minutes).

No adverse events related to vitamin K2 use were identified.

Vitamin K2 in Managing Nocturnal Leg Cramps
A Randomized Clinical Trial
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