Железа бисглицинат при ЖДА

[Marat1337]

Здравствуйте, Вадим Валерьевич. Я ординатор-гематолог, заметил, что Вы рекомендуете железа бисглицинат? Так как всасывается аминокислотным транспортом и меньше траблит ЖКТ? Спасибо.
2. Какую литературу порекомендуете для изучение гематологии? Спасибо

[Dr.Vad]

The structural and absorption characteristics of FeBC and FeP may contribute to the differences in their bioavailability and efficacy when compared to other compounds. Several studies showed that FeBC has high bioavailability, better absorption, higher efficacy in increasing hemoglobin and ferritin levels, and greater performance in treating IDA compared to ferrous sulfate [8, 13, 36-41]. The bioavailability of FeP, in turn, was described as similar to that of ferrous sulfate [7, 12, 16, 17]. However, studies indicate lower bioavailability of this compound compared to ferrous sulfate or fumarate [18-21].

Iron bisglycinate chelate has a stable structure, with a molecular weight of approximately 204 daltons (Da), whereas FeP are complexes with molecular weights between 50,000 and 452,000 Da [42]. High molecular weight compounds may be more difficult for the body to absorb. For example, amino acid-chelated minerals should have a maximum molecular weight of 1,000-1,500 Da to be properly absorbed [43, 44]. Likewise, a dramatic reduction in bioavailability was observed for macromolecules above 600 Da [45, 46]. Therefore, these differences in their structures and size may contribute to different absorption rates.

The mechanisms of iron absorption differ between FeBC and FeP. FeP has a slow rate of iron transfer from the intestinal lumen to the portal circulation. One study in rats showed that this transfer rate peaked at 30 minutes with ferrous ascorbate, in contrast to 24 hours required for FeP [47], whereas the absorption of FeBC was higher than that of ferrous sulfate (8.68% vs. 1.34%, p<0.0001) in a study using a dual-radioisotope method. FeBC was consistently 5.3 times more absorbed than ferrous sulfate, and this ratio was not altered by the simultaneous consumption of both compounds, indicating no exchange between the two iron sources in the intestinal pool or before entering the mucosa – if there were such an exchange, equal proportions of the two compounds would be absorbed. This result indicates that FeBC enters the cellular mucosa in a chelated form [44], which reinforces the importance of structure and size of the compound in determining its absorption. [Ссылки доступны только зарегистрированным пользователям ]
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Гематология Винтроба или Хоффмана, лучше в оригинале, ибо отечественные переводчики еще те https://forums.rusmedserv.com/showthread.php?p=2808811

[Marat1337]

Спасибо, Вадим Валерьевич. Если что можно с Вами консультироваться по поводу клин случаем, если Вы не против, конечно?

[Dr.Vad]

да, пишите в новой теме, если можете подробнее и со сканами анализов, удалив из них фио пациента

[Marat1337]

Огромное спасибо! Хочу учиться у лучших!