#61
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Нарыл тут в Кокране..
The Cochrane Database of Systematic Reviews 2005 Issue 4 Copyright © 2005 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Probiotics for treating infectious diarrhoea Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF Abstract Background Probiotics are microbial cell preparations or components of microbial cells that have a beneficial effect on the health and well being of the host. Probiotics may offer a safe intervention in acute infectious diarrhoea to reduce the duration and severity of the illness. Objectives To assess the effects of probiotics in proven or presumed infectious diarrhoea. Search strategy We searched the Cochrane Infectious Diseases Group's trials register (December 2002), the Cochrane Controlled Trials Register (The Cochrane Library Issue 4, 2002), MEDLINE (1966 to 2002), EMBASE (1988 to 2002), and reference lists from studies and reviews. We also contacted organizations and individuals working in the field, and pharmaceutical companies manufacturing probiotic agents. Selection criteria Randomized controlled trials comparing a specified probiotic agent with placebo or no probiotic in people with acute diarrhoea that is proven or presumed to be caused by an infectious agent. Data collection and analysis Two reviewers independently assessed trial methodological quality and extracted data. Main results Twenty-three studies met the inclusion criteria with a total of 1917 participants, mainly in countries with low overall mortality rates. Trials varied in relation to the probiotic(s) tested, dosage, methodological quality, and the diarrhoea definitions and outcomes. Probiotics reduced the risk of diarrhoea at 3 days (relative risk 0.66, 95% confidence interval 0.55 to 0.77, random effects model; 15 studies) and the mean duration of diarrhoea by 30.48 hours (95% confidence interval 18.51 to 42.46 hours, random effects model, 12 studies). Subgroup analysis by probiotic(s) tested, rotavirus diarrhoea, national mortality rates, and age of participants did not fully account for the heterogeneity. Authors' conclusions Probiotics appear to be a useful adjunct to rehydration therapy in treating acute, infectious diarrhoea in adults and children. More research is needed to inform the use of particular probiotic regimens in specific patient groups. [Ссылки доступны только зарегистрированным пользователям ] |
#62
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Вроде такой ссылки не было
BMJ. 2002 June 8; 324(7350): 1361. [Ссылки доступны только зарегистрированным пользователям ] Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis Aloysius L D'Souza, research fellow, Chakravarthi Rajkumar, senior lecturer and honorary consultant, Jonathan Cooke, statistician, and Christopher J Bulpitt, professor of geriatric medicine "Conclusions The meta-analysis suggests that probiotics can be used to prevent antibiotic associated diarrhoea and that S boulardii and lactobacilli have the potential to be used in this situation. The efficacy of probiotics in treating antibiotic associated diarrhoea remains to be proved. A further large trial in which probiotics are used as preventive agents should look at the costs of and need for routine use of these agents." |
#63
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[Ссылки доступны только зарегистрированным пользователям ]
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#64
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Надо бы приподнять эту тему. А то совсем потеряется.
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#65
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Целиакия
Уважаемые доктора и участники форума. Я студент 4 курса УГМА, уже три года страдаю дерматитом Дюринга. По этиологии он схож с целиакией, так же непереносимость глютена. Но мне интересно, есть ли что-то еще общего у этих двух нозологий?
И еще, если не трудно, подскажите: может ли дисбактериоз препятствовать действию препаратов, в частности сульфасалазина, которым я лечился полтора года, а теперь он мне не помогает. Если да, то каким образом? Заранее спасибо! с уважением MIK. |