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#2
22.05.2007, 17:20
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Другим заинтересованным лицам тоже можно почитать?
 
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#3
22.05.2007, 20:35
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Цитата:
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#5
07.08.2007, 00:12
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Спасибо за суммарный эвиденс по резистентности к клопигодрелю, но все же пока вопрос остается открытым - рациональнее тестировать всех пациентов на этот феномен (и какими лаб. тестами?) и затем по выявлению повышать дозу (однократно или до преодоления резистентности?) клопидогреля или же всем заряжать сразу повышенную нагрузочную и повышенную поддерживающую?
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#6
29.10.2007, 13:35
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The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease
[Ссылки доступны только зарегистрированным пользователям ]
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#7
23.01.2008, 23:25
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Especially for Gilarov and dav1972
Circulation. 2007 Nov 27;116(22):2531-4. Epub 2007 Nov 12.
Atrial fibrillation ablation in patients with therapeutic international normalized ratio: comparison of strategies of anticoagulation management in the periprocedural period. [Ссылки доступны только зарегистрированным пользователям ]
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#8
04.03.2008, 18:15
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Comparison of Risk Stratification Schemes to Predict Thromboembolism in People With Nonvalvular Atrial Fibrillation. [Ссылки доступны только зарегистрированным пользователям ]
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#10
10.04.2008, 22:03
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J Am Coll Cardiol. 2008 Apr 8;51(14):1404-11.
Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study. Bonello L, Camoin-Jau L, Arques S, Boyer C, Panagides D, Wittenberg O, Simeoni MC, Barragan P, Dignat-George F, Paganelli F. Service de Cardiologie, Hôpital Universitaire Nord, Marseille, France. OBJECTIVES: This study evaluates the clinical impact of adjusting the loading dose of clopidogrel according to vasodilator-stimulated phosphoprotein (VASP) index in patients with clopidogrel resistance undergoing percutaneous coronary intervention (PCI). BACKGROUND: Clopidogrel resistance plays a key role in ischemic recurrence after PCI. In vitro tests of clopidogrel resistance can accurately predict major adverse cardiac events after PCI. METHODS: In this prospective, randomized, multicenter study, clopidogrel resistance was defined as a VASP index of more than 50% after a 600-mg loading dose. Patients with clopidogrel resistance undergoing coronary stenting were randomized to a control group or to the VASP-guided group, in which patients received additional bolus clopidogrel to decrease the VASP index below 50%. RESULTS: A total of 162 patients were included. The control (n = 84) and VASP-guided groups (n = 78) had similar demographic, clinical, and biological characteristics. In the VASP-guided group, dose adjustment was efficient in 67 patients (86%) and VASP index was significantly decreased (from 69.3 +/- 10 to 37.6 +/- 13.8; p < 0.001). Eight major adverse cardiac events (5%) were recorded during the 1-month follow-up, with a significantly lower rate in the VASP-guided group compared with the control group (0% vs. 10%; p = 0.007). There was no difference in the rate of major and minor bleeding (5% vs. 4%; p = 1). CONCLUSIONS: This is the first study to suggest that adjusting the clopidogrel loading dose according to platelet monitoring using the VASP index is safe and may significantly improve the clinical outcome after PCI in patients with clopidogrel resistance despite a first 600-mg loading dose.
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#11
11.04.2008, 11:46
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Цитата:
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#12
30.04.2008, 18:11
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To Igor73
Pulmonary Arterial Hypertension
J. Am. Coll. Cardiol. 2008;51;1527-1538 Kelly M. Chin, and Lewis J. Rubin [Ссылки доступны только зарегистрированным пользователям ]
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#13
16.08.2008, 13:13
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Prehospital initiation of tirofiban in patients with
ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial [Ссылки доступны только зарегистрированным пользователям ] Gilles Montalescot Mechanical reperfusion: treat well, treat on time too [Ссылки доступны только зарегистрированным пользователям ]
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#14
23.08.2008, 16:15
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?
Михаил Юрьевич, эту статью искали?
Potential of non-antiarrhythmic drugs to provide an innovative upstream approach to the pharmacological prevention of sudden cardiac death. [Ссылки доступны только зарегистрированным пользователям ]
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#15
28.08.2008, 13:46
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Спасибо, уважаемый Модератор, за выделение этой темы. Еще, как-нибудь придумать, что бы закаченные документы висели максимально долго.
Д-ру audovichenko: Incidence and Clinical Impact of Dual Nonresponsiveness to Aspirin and Clopidogrel in Patients With Drug-Eluting Stents [Ссылки доступны только зарегистрированным пользователям ] Aspirin Resistance An Underestimated Risk in Patients With Drug-Eluting Stents? [Ссылки доступны только зарегистрированным пользователям ] Все желающим: Heart Disease and Stroke Statistics 2008 Update: [Ссылки доступны только зарегистрированным пользователям ]
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Линейный вид
