Да, такая мысль о профилактике на фоне постоянного лечения метформином была высказана, например, здесь:
Metformin-induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy - David S.H. Bell, MD - South Med J. 2010;103(3):265-267 ([
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Цитата:
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Therefore, in those patients who have been on long-term metformin, an annual vitamin B12 level should be obtained. Perhaps a more practical and cost-effective approach would be to give every patient on metformin an annual 1000 microgram injection of vitamin B12 which is sufficient to cover vitamin B12 needs for at least a year. An alternative therapy would be to prophylactically administer calcium carbonate (1.2 grams daily) which may also correct the "loose stools" associated with metformin therapy.[10]
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