The Journal of Clinical Endocrinology & Metabolism, 2021, Vol. 106, No. 9, 2600–2605
doi:10.1210/clinem/dgab373
Clinical Research Article
ISSN Print 0021-972X ISSN Online 1945-7197
Printed in USA 2600 [Ссылки доступны только зарегистрированным пользователям ] © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
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Clinical Research Article
Three Cases of Subacute Thyroiditis Following
SARS-CoV-2 Vaccine: Postvaccination ASIA
Syndrome
Burçin Gönül İremli,1
Süleyman Nahit Şendur,1
and Uğur Ünlütürk1
1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University
School of Medicine, Hacettepe, Ankara, Turkey
ORCiD number: 0000-0002-5054-1396 (U. Ünlütürk).
Received: 24 April 2021; Editorial Decision: 21 May 2021; First Published Online: 27 May 2021; Corrected and Typeset:
24 June 2021.
Abstract
Context: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome)
can be seen as a postvaccination phenomenon that occurs after exposure to adjuvants
in vaccines that increase the immune responses. There are very limited data regarding
ASIA syndrome following severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines.
Objectives: This work aims to report cases of subacute thyroiditis related to the SARSCoV-2 vaccine.
Methods: We describe the clinical, laboratory, and imaging features of 3 cases of
subacute thyroiditis after inactivated SARS-CoV-2 vaccine (CoronaVac®). Three female
healthcare workers have applied to our clinic with anterior neck pain and fatigue 4 to
7 days after SARS-CoV-2 vaccination. Two of them were in the breastfeeding period.
They were negative for thyroid antibodies, and there was no previous history of thyroid
disease, upper respiratory tract infection, or COVID-19. Laboratory test results and
imaging findings were consistent with subacute thyroiditis.
Results: SARS-CoV-2 vaccination can lead to subacute thyroiditis as a phenomenon of
ASIA syndrome. Subacute thyroiditis may develop within a few days after the SARSCoV-2 vaccination. Being in the postpartum period may be a facilitating factor for the
development of ASIA syndrome after the SARS-CoV-2 vaccination.
Conclusions: This is the first report of subacute thyroiditis as a phenomenon of ASIA
syndrome after inactivated COVID-19 vaccination. Clinicians should be aware that
subacute thyroiditis may develop as a manifestation of ASIA syndrome after the inactive
А вот уже природа играет в нашей песочнице - если был подострый на ковиде, логично, что он есть и на вакцину.
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