В SAFE, VASST, LIPOS Trial 3, CORTICUS and More: Implications for the Surviving Sepsis Campaign Guidelines :
Цитата:
Another recently completed European clinical trial compared NE with epinephrine for hemodynamic support in 330 patients with septic shock.[11] The study endpoint was mortality rate at 28 days. There were no differences in mortality rate, blood pressure, time to hemodynamic stability, duration of vasopressor therapy, or time to resolution of organ dysfunction. There were similar adverse events (ie, cardiac and neurologic effects) associated with both drugs
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и :
Цитата:
The original SSC guidelines do not dictate specific vasopressor therapy, but rather focus more on the adequacy and immediacy of therapy
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Получается норадреналин-уже не "лучший выход",можно и адреналин? И сравнение его с мезатоном : отличие только в более мощном вазоконстрикторном эффекте..Значит мезатон(в адекватных дозах)-замена норадр..?