вот пример, как вели детей в колорадском Денвере, США, но в рамках клинического исследования: у 112 детей были антитела и в течение 5 лет наблюдения за ними у 30 развился диабет:
112 have developed islet autoantibodies and 30 have progressed to diabetes; median of 5.3 years, and 25% have been followed for 8 years or more
их наблюдали с интервалом каждые 3-6 мес., но родители были предупреждены о первых симптомах диабета:
If a child was found to be autoantibody positive, the family was notified of the result and instructed in symptoms of hyperglycemia. They were then followed in the study clinic every 3–6 months for islet autoantibodies, HbA1c, and random blood glucose obtained on a glucometer. Referral for evaluation by a pediatric endocrinologist was initiated if the child was symptomatic, if the random blood glucose was elevated (>6 mmol/l), or if the HbA1c increased toward the upper limit of the normal range (6.4%).
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