In Vivo Regeneration of Insulin-Producing beta-Cells.
Jun HS.
Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, 7-45 Sondo-dong, Yeonsu-ku, Incheon, 406-840, Korea, [Ссылки доступны только зарегистрированным пользователям ].
Abstract
Type 1 and type 2 diabetes mellitus are considered to be caused by defective control of blood glucose resulting from a reduced beta-cell mass. Thus, the restoration of a functional beta-cell mass by replacing the damaged beta-cells or stimulating beta-cell regeneration is a logical approach for the treatment of diabetes. Strategies for increasing the beta-cell mass include stimulating beta-cell replication and differentiation and inhibiting beta-cell death. Treatment with various growth factors such as GLP-1, BTC, HGF, and EGF and forced expression of beta-cell transcription factors such as Pdx-1, NeuroD, and MafA resulted in the regeneration of beta-cells in vivo. Another approach is the administration of stem/progenitor cells, which can differentiate into insulin-producing cells. However, there are no satisfactory methods yet for clinical application. Understanding the mechanisms of the regenerative process of pancreatic beta-cells will pave the way for the development of regenerative medicine for treatment of diabetes.
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Г.А. Мельниченко
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