1/ You are correct. On Mtx treatment we do sometimes see increase in the nodule size and and also new nodules can appear. This is not a reason to stop treatment.
2/ Heterozygouse factor II does NOT increase the risks of recurrent VTE. Six months is Ok. (The risk of recurrent venous thromboembolism among heterozygous carriers of the G20210A prothrombin gene mutation.
AU De Stefano V; Martinelli I; Mannucci PM; Paciaroni K; Rossi E; Chiusolo P; Casorelli I; Leone G SO Br J Haematol 2001 Jun;113(3):630-5.)
3/ Transfusion related Graft-Versus-Host disease can be prevented by irradiating the blood products. Normally transfusion related GVHD does NOT happen because the donor WBCs are killed by the hosts immune system. There are two reasons why this can occure. 1/ immunosupression 2/ partial or complete HLA match. This second reason is why all blood products (platelets, RBCs etc) should be irradiated. By the way there in NO treatment for transfusion related GVHD, mortality 90%.
4/ As you rightly pointed out thre is a connection between the alcohol and those cancers.
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