Хороший вопрос - к сожалению, сегодня нам известно только то, что известно вообще на сегодняшний день:
Although all patients with overt HFE-related HC (i.e., with organ damage) carry the C282Y mutation on both HFE alleles, some C282Y homozygotes present no evidence of organ disease or biochemical abnormalities, although they should still be considered to be at increased risk. It is currently impossible to predict whether (and to what extent) a C282Y homozygote will express the disease phenotype. At present, we can only conclude that although the majority of C282Y homozygotes have laboratory evidence of plasma and tissue iron overload (i.e., high transferrin saturation and ferritin levels, respectively), organ disease requiring medical treatment is much less common today. (Annu Rev Nutr. 2006;26:251-70.)
Полагаю, в любом случае следует проводить генет. исследования.
Мы не знаем с какого времени у Вас повышенная сатурация трансферрином железа, железо может/могло теряться через ЖКТ (2-3 мл в день порой достаточно для развития железодефицита) и т.п.
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