[Dr.Vad]

У женщин в возрасте 18-40 лет низкодозовый аспирин (81 мг в день), назначенный в период перед зачатием, всего на 14% повышает шансы на донашивание, если было 1-2 эпизода невынашивания на любом сроке, и на 28%, если было одно невынашивание на сроке до 20 недель, в сравнении с пацебо:

J Clin Endocrinol Metab. 2015 Feb 24:jc20144179.
Preconception Low Dose Aspirin and Time to Pregnancy: Findings from the EAGeR (Effects of Aspirin in Gestation and Reproduction) Randomized Trial.
Schisterman EF и соавт.

Objective: To determine the effect of preconception-initiated daily low-dose aspirin (LDA; 81 mg/day) treatment on time to pregnancy in women with a history of pregnancy loss.

Design: Multi-center, block-randomized, double-blind, placebo-controlled trial. Participants were block-randomized by center and eligibility stratum. Setting: Four U.S.A. medical centers (2007-2012). Participants: Women aged 18-40 years actively attempting pregnancy, stratified by eligibility criteria-the "original" stratum, women with one loss <20 weeks' gestation during the previous year; and the "expanded" stratum, women with one or two previous losses of any gestational age regardless of time since loss.

Intervention: Daily LDA was compared with matching placebo for up to six menstrual cycles of attempting pregnancy.

Main outcome measure: Time to hCG detected pregnancy and clinically confirmed pregnancy, analyzed by intention-to-treat.

Results: Of the 1228 women randomly assigned to LDA (n=615) or placebo (n=613), 410 (67%) women receiving LDA achieved pregnancy compared to 382 (63%) receiving placebo, corresponding to a fecundability odds ratio (FOR) of 1.14 (95% CI: 0.97, 1.33). Among women in the original stratum (n=541), LDA was associated with increased fecundability compared to placebo (FOR: 1.28; 95%CI: 1.02, 1.62).

Conclusions: Preconception-initiated LDA treatment resulted in a nonsignificant increase in fecundability of 14% in women with a history of 1-2 pregnancy losses, and a significant increase of 28% in women with a history of only one pregnancy loss of <20 weeks' gestation in the preceding year. Preconception-initiated LDA may increase fecundability in certain women with a recent early pregnancy loss.