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The cis-AB blood group phenotype: fundamental lessons in glycobiology.
Yazer MH, Olsson ML, Palcic MM.
The Institute for Transfusion Medicine and Department of Pathology, University of Pittsburgh, PA 15213, USA. [
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The cis-AB phenotype can raise questions about an apparently paradoxical inheritance of the ABO blood group, such as the birth of an O child from an AB mother. These subtype ABO alleles confer the ability to create both A and B antigens with a single enzyme. A variety of different cis-AB enzymes have been reported and many feature an interchange of amino acids between the normal A enzyme sequence and its B counterpart, rendering the mutant enzyme capable of creating both antigens. The resulting red blood cells do not usually express A or B antigen at the same level that would be expected on common group A(1) or B red blood cells, and the results of investigations into the kinetics of the cis-AB enzyme more clearly predict the extent of antigen expression. By correctly identifying the cis-AB phenotype, the blood bank can be of assistance to a clinician faced with a patient with what appears to be a genetically impossible ABO blood group.
PMID: 16787828 [PubMed - indexed for MEDLINE]
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[AB-cis phenotype with expression similar to AB-el]
[Article in Spanish]
González Campos J, Jiménez Jiménez JM, Caso Sanz F, Pérez Garrido R, Rodríguez Fernández JM.
Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Sevilla.
We studied a discrepancy between red blood cells and serum test. The red cell test was identified as an A group, and the serum test as an AB group. Then we performed adsorption-elution and saliva test, in order to demonstrate A, B and H substances. We found that the blood group was AB, and the B antigen belonged to a weak group named Bel. We studied her parent blood groups. Her mother was AB and her father 0. We conclude that the blood group belonged to an cis-AB phenotype and the B antigen was a weak Bel variant.
PMID: 8779036 [PubMed - indexed for MEDLINE]