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Rare but very disturbing are scintillations noticed when the eyes are open or closed.

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Flammer syndrome in healthy people
Most individuals with FS are healthy, even notably physically and mentally active and usually successful in their professional lives. They normally do not feel sick, because for them, symptoms have more or less always been present, and often their mother or father had the same. Although FS symptoms can be troublesome, FS people normally learn to deal with them, for example, by avoiding coldness, putting on socks at night, increasing salt intake, or adapting doses of drugs.

Flammer syndrome as a protective factor
Based on clinical experience, FS subjects have a good life expectancy. This can be explained by the low frequency of classical cardiovascular risk factors such as arterial hypertension, hypercholesterolemia, obesity, or diabetes. However, people with increased cold sensitivity in the extremities are additionally protected against metabolic syndrome, probably by an increased level of adiponectin [7]. Nevertheless, FS can be a risk factor for some diseases discussed in this review.

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