С Медскейпа: Pediatric Hyperthyroidism - Sunil Sinha, MD; Chief Editor: Stephen Kemp, MD, PhD ([
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Цитата:
Dosage and frequency of administration for these medications have not been well established. The initial pediatric dose of methimazole is administered at 0.4-0.7 mg/kg/d. Its half-life is 4-6 hours. The usual pediatric dose of PTU is 5-7 mg/kg/d; its serum half-life is 75 minutes. Pharmacokinetically, it would seem that neither of these should be effective as once-daily therapy; yet, because the thyroid accumulates the drugs, methimazole given once daily is clinically effective. However, PTU should be administered 3 times a day.
Lower per-kilogram doses of methimazole (< 0.5 mg/kg/d) have been shown to prolong the free T 4 elevations for almost 3 times as long as the higher per-kilogram doses (>0.5 mg/kg/d).
Because antithyroid medications affect the thyroid principally at the level of hormone biosynthesis, patients may continue to secrete preformed hormone for 6-12 weeks after initiation of therapy.
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Hyperthyroidism in Children- Shylaja Srinivasan,MD, MadhusmitaMisra,MD,MPH, *Pediatric Endocrine Unit, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA - Pediatrics in Review 2015;36;239 DOI: 10.1542/pir.36-6-239:
Цитата:
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After initiation of methimazole therapy, thyroid function tests are generally repeated in 2 weeks and then monthly until values normalize. Depending on disease severity, thyroid function tests may not normalize for several months. After normalization of thyroid hormone concentrations,thyroid function tests should be monitored every 3 to 4 months.
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Хотя чаще всего конрроль осуществляется по свТ4 как несколько менее "лабораторно капризному" анализу...