Цитата:
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Сообщение от Sergnt
Пока есть мнение, что статины непосредственно на рестеноз не влияют.
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J Interv Cardiol. 2004 Oct;17(5):301-6.
Restenosis after successful ostial stent implantation: the role of statins compared with conventional treatment.
Horlitz M, Amin FR, Boerrigter G, Sigwart U, Clague JR.
Department of Cardiology, HELIOS Klinikum Wuppertal, Heartcenter Wuppertal, University of Witten/Herdecke, Arrenberger Strasse 20, D-42117 Wuppertal, Germany.
Despite the introduction of coronary stents and effective anticoagulation regimens, the treatment of ostial lesions is limited by high restenosis rates. Initial results have been published asserting that statin therapy is associated with a significant reduction in restenosis after stent deployment. However, no information is available about the effect of statins after ostial stenting. Between 1993 and 2000, 122 patients required ostial placement of coronary stents at the Royal Brompton Hospital in London, United Kingdom. Statin treatment was continued or begun in 52 patients with a documentated hypercholesterolemia. Follow-up was feasible in 97 patients undergoing successful stent implantation. Restenosis rate was lower in patients receiving statins, but did not differ significantly from the nonstatin group (34.6% as against 42.2%, P = 0.531).
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J Cardiol. 2005 Mar;45(3):107-13.
Combined treatment with statin and angiotensin-receptor blocker after stenting as a useful strategy for prevention of coronary restenosis.
Nishikawa H, Miura S, Shimomura H, Tsujita K, Okamura K, Zhang B, Iwata A, Shirai K, Matsuo K, Arai H, Saku K.
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka.
OBJECTIVES: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) enhances the inhibitory effects of angiotensin-receptor blocker (ARB) on vascular neointimal formation in mice. The present case-control study investigated the efficacy of combined treatment with statin and ARB for preventing restenosis in patients with coronary artery disease. METHODS: We examined 210 patients with angina pectoris undergoing elective coronary stenting for de novo lesions of native coronary arteries. All enrolled patients received aspirin and ticlopidine. The subjects included patients who received no statin (control group, n = 137) or started statin treatment (statin group, n = 73) with or without ARB treatment after stenting. RESULTS: The rate of restenosis at 6 months after stent implantation in the statin group (19%) was significantly lower than that in the control group (32%). The restenosis rate in self-expanding Radius stents. (23%) was significantly lower than that in balloon-expandable Velocity stents (42%) independent of statin treatment. Patients treated with statins and ARBs were least likely [odds ratio (95% confidence interval): 0.30 (0.12-0.74)] to develop coronary restenosis, as assessed by multiple logistic regression analysis. CONCLUSIONS: These findings indicate that combined treatment with statin and ARB after stenting is a useful strategy for the prevention of coronary restenosis.
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J Atheroscler Thromb. 2005;12(6):302-6.
Effect of statin on restenosis after radius stent implantation in patients with acute coronary syndrome.
Nishikawa H, Miura S, Shimomura H, Kawamura A, Tsujita K, Shirai K, Matsuo K, Arai H, Saku K.
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Despite reports that statin treatment reduces the rate of coronary restenosis with a balloon expandable stent, there is no evidence that statins affect the incidence of restenosis with a self-expanding Radius stent. Ninety-five patients with acute coronary syndrome who had been implanted with a Radius stent were classified into two groups: those with hyperlipidemia and initial statin treatment (statin group, n = 38) and those without statin treatment (comparative group, n = 57). At six months after stent implantation, the rate of coronary restenosis was significantly lower in the statin group (10.5%) than control group (28.1%) (p = 0.033), while there were no differences in morphology, maximal inflation pressure or stent size between the two groups. Interestingly, there was no difference in the serum lipid profile between the two groups at the 6-month follow-up, although the statin group had a significantly lower rate of restenosis. In conclusion, initial statin therapy reduced the rate of coronary restenosis even when a Radius stent was implanted.