[Maltsev]

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Conclusions

Compared with usual care, in low-to-moderate risk NYHA class II and III systolic heart failure patients, exercise-based intervention reduces heart failure-related hospitalizations and results in clinically important improvements in HRQoL. Exercise training did not reduce or increase all-cause mortality. Any effect of cardiac exercise training on total mortality and HRQoL was independent of degree of left ventricular dysfunction, type of cardiac rehabilitation, dose of exercise intervention, length of follow-up, trial quality, and trial publication date. High-quality RCT and cost-effectiveness evidence is needed to assess the effect of exercise training in community-based settings and in more severe heart failure patients, elderly people, and women.