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Di Sciascio et al say their results in the unstable cohort are "hypothesis generating" and should be confirmed in larger trials, but Di Sciascio told heartwire that further trials might be difficult to do now because most cardiologists already intuitively believe that reloading clopidogrel is the correct course of action in unstable patients, and this is what is happening in practice. "We often see this situation--that practice is ahead of academic studies," he added.
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