[Dr.Vad]

Еще как пример от местных докторов, когда приходится прибегать к вот такой необычной комбинации у детей, когда аблацию технически трудновыполнима и чревата осложнениями:

Ten patients (median age: 29 days, range: 1 to 241 days) failed at least two antiarrhythmic agents including either flecainide or sotalol as single agents before initiating combination therapy. Efficacy was achieved in all patients. The failure rate for therapy was reduced from 100% to 0% (95% confidence interval: 0% to 26%). The median doses used were: flecainide 100 mg/m(2)/day (range: 40 to 150 mg/m(2)/day) and sotalol 175 mg/m(2)/day (range: 100 to 250 mg/m(2)/day). Median duration of therapy was 16 months (range: 5 to 35 months). No proarrhythmia occurred.
The combination of flecainide and sotalol can safely and effectively control refractory SVT and may obviate the need for RFA in children <1 year.
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J Am Coll Cardiol. 2002 Feb 6;39(3):517-20.
Flecainide and sotalol: a new combination therapy for refractory supraventricular tachycardia in children <1 year of age.
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