Что делают, если пациенты жалуются на миалгии при приеме статинов в США:
... self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use.
Of the respondents, 60% of former statin users (n = 1220) reported ever experiencing new or worsened muscle pain on a statin, in contrast to 25% of current users (n = 8918; P < .001). Former statin users reported stopping more statins because of muscle symptoms (mean ± standard deviation, 2.2 ± 1.7) compared with current users (mean 1.6 ± 1.5, P < .0001). For those with muscle-related symptoms while on a statin, participants reported that providers most often suggested switching to another statin (33.8%), stopping the statin (15.9%), continuing the statin with further monitoring of muscle symptoms (12.2%), reducing the statin dose (9.8%), or getting a blood test for signs of muscle damage (9.2%). A lower percentage were advised to add either vitamin D (7.0%) or coenzyme Q10 (5.8%), or to switch to nonstatin therapy (6.1%) or red yeast rice (2.6%).
---
Provider recommendations for patient-reported muscle symptoms on statin therapy: Insights from the Understanding Statin Use in America and Gaps in Patient Education survey.
[Ссылки доступны только зарегистрированным пользователям ]
Откуда растут ноги у повышенного интереса к витамину Д в полной версии:
Khayznikov M, et al.
Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D Supplementation.
N Am J Med Sci. 2015;7:86–93. [Ссылки доступны только зарегистрированным пользователям ]
переписка:
Statin Intolerance and Vitamin D Supplementation: Sunny, but a Few Clouds Remain… [Ссылки доступны только зарегистрированным пользователям ]
Statin Intolerance and Vitamin D Supplementation. [Ссылки доступны только зарегистрированным пользователям ]
Safety of 50,000-100,000 Units of Vitamin D3/Week in Vitamin D-Deficient, Hypercholesterolemic Patients with Reversible Statin Intolerance
[Ссылки доступны только зарегистрированным пользователям ]
Atherosclerosis. 2017 Jan;256:125-127.
Low serum vitamin D, statin associated muscle symptoms, vitamin D supplementation. [Ссылки доступны только зарегистрированным пользователям ]
А если скрестить бульдога с носорогом?
Effects of vitamin D on plasma lipid profiles in statin-treated patients with hypercholesterolemia: A randomized placebo-controlled trial.
[Ссылки доступны только зарегистрированным пользователям ]
|