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Сообщение от Gilarov
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[url="http://circ.ahajournals.org/cgi/content/abstract/120/23/2322"]The propensity score–adjusted rate ratio for the primary end point of myocardial infarction or death was 1.22 (95% confidence interval, 0.99 to 1.51); for death, 1.20 (95% confidence interval, 0.84 to 1.70); and for revascularization, 0.97 (95% confidence interval, 0.79 to 1.21). Matched analyses generally yielded similar results.
Conclusions— Although point estimates indicated a slightly increased risk of myocardial infarction hospitalization or death in older patients initiating both clopidogrel and a PPI, we did not observe conclusive evidence of a clopidogrel-PPI interaction of major clinical relevance. Our data suggest that if this effect exists, it is unlikely to exceed a 20% risk increase.
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Доверительные интервалы включают 1, значит, вероятность событий в группе клопидогрела c PPI не отличается от вероятности в контрольной группе.