Да, а вот ссылка вышеупомянутое исследование в NEJM: [Ссылки доступны только зарегистрированным пользователям ]
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Тем не менее, бельгийцы продолжают будоражить общественность новыми чрезвычайными доказательствами. Очередное исследование в The Lancet, на этот раз исследовалась педиатрическая популяция:

Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study

Dirk Vlasselaers*, Ilse Milants*, Lars Desmet*, Pieter J Wouters, Ilse Vanhorebeek, Ingeborg van den Heuvel, Dieter Mesotten,
Michael P Casaer, Geert Meyfroidt, Catherine Ingels, Jan Muller, Sophie Van Cromphaut, Miet Schetz, Greet Van den Berghe
Lancet 2009; 373: 547–56


Summary
Background Critically ill infants and children often develop hyperglycaemia, which is associated with adverse outcome;
however, whether lowering blood glucose concentrations to age-adjusted normal fasting values improves outcome is
unknown. We investigated the eff ect of targeting age-adjusted normoglycaemia with insulin infusion in critically ill
infants and children on outcome.

Methods In a prospective, randomised controlled study, we enrolled 700 critically ill patients, 317 infants (aged <1 year)
and 383 children (aged ≥1 year), who were admitted to the paediatric intensive care unit (PICU) of the University
Hospital of Leuven, Belgium. Patients were randomly assigned by blinded envelopes to target blood glucose
concentrations of 2·8–4·4 mmol/L in infants and 3·9–5·6 mmol/L in children with insulin infusion throughout
PICU stay (intensive group [n=349]), or to insulin infusion only to prevent blood glucose from exceeding 11·9 mmol/L
(conventional group [n=351]). Patients and laboratory staff were blinded to treatment allocation. Primary endpoints
were duration of PICU stay and infl ammation. Analysis was by intention to treat. This study is registered with
ClinicalTrials.gov, number NCT00214916.

Findings Mean blood glucose concentrations were lower in the intensive group than in the conventional group
(infants: 4·8 [SD 1·2] mmol/L vs 6·4 [1·2] mmol/L, p<0·0001; children: 5·3 [1·1] mmol/L vs 8·2 [3·3] mmol/L,
p<0·0001). Hypoglycaemia (defi ned as blood glucose ≤2·2 mmol/L) occurred in 87 (25%) patients in the intensive
group (p<0·0001) versus fi ve (1%) patients in the conventional group; hypoglycaemia defi ned as blood glucose less
than 1·7 mmol/L arose in 17 (5%) patients versus three (1%) (p=0·001). Duration of PICU stay was shortest in the
intensively treated group (5·51 days [95% CI 4·65–6·37] vs 6·15 days [5·25–7·05], p=0·017). The infl ammatory
response was attenuated at day 5, as indicated by lower C-reactive protein in the intensive group compared with
baseline (–9·75 mg/L [95% CI –19·93 to 0·43] vs 8·97 mg/L [–0·9 to 18·84], p=0·007). The number of patients with
extended (>median) stay in PICU was 132 (38%) in the intensive group versus 165 (47%) in the conventional group
(p=0·013). Nine (3%) patients died in the intensively treated group versus 20 (6%) in the conventional
group (p=0·038).

Interpretation Targeting of blood glucose concentrations to age-adjusted normal fasting concentrations improved
short-term outcome of patients in PICU. The eff ect on long-term survival, morbidity, and neurocognitive
development needs to be investigated.

Здесь обзор-перевод в моем скромном исполнении на сайте medmir.com: [Ссылки доступны только зарегистрированным пользователям ]

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