Еще одно свидетельство, что хранение/транспортировка крови снижают абс. число нейтрофилов (и моноцитов), поэтому в транспортировочных образцах чаще будет выявлятся идиопатическая нейтропения, которая может приводить к ненужным волнениям и напрасным дообследованиям:
Clin Biochem. 2013 Feb;46(3):278-81.
Comparison of hematologic measurements between local and central laboratories: data from the BABY HUG trial.
Kalpatthi R1, Thompson B, Lu M, Wang WC, Patel N, Kutlar A, Howard T, Luchtman-Jones L, Miller ST; BABY HUG Investigators.
Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
OBJECTIVES: To investigate the concordance of blood count indices measured locally and at a central laboratory.
DESIGN AND METHODS: In a multi-center clinical trial of hydroxyurea therapy in infants with sickle cell anemia (BABY HUG), the concordance between blood count indices measured locally and at a central laboratory was investigated.
RESULTS: Local laboratory measurements of neutrophil and monocyte counts were significantly higher (44% and 37%, respectively) compared to the central measurements (p<0.0001), and mean corpuscular volume (MCV) was higher centrally.
CONCLUSION: Overnight shipping with processing delay causes spurious reductions in absolute neutrophil count (ANC) and absolute monocyte count (AMC) that may result in incorrect monitoring decisions in multicenter clinical trials.
|