
26.02.2012, 09:57
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Регистрация: 29.04.2009
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Цитата:
Opinions about metamizol are controversial. In some countries, metamizol was withdrawn already in the 70ties of the previous century; in others, it is still widely used.
According to the Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, the number of adverse effects registered in the years 1978-2009 (March) was 14441 for metamizol and 67581 for paracetamol.
Modern multimodal analgesia should be based on a good combination of analgesics. Both metamizol and paracetamol may be used for such a purpose, yet in the lowest effective doses, within the shortest needed time and once evident contraindications have been considered. Safety of both drugs is several times higher than that of commonly used NSAIDs.
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Цитата:
Myelotoxicity of metamizol has been disputed for years. In Sweden, metamizol was banned in 1974, in the USA in 1977. Similar steps were taken by other 30 countries including Japan, Australia, Iran and some European Union countries. In many countries, e.g. Spain, Mexico, India, Egypt, Brazil, Poland, Russia, Turkey, Bulgaria and Germany, metamizol, usually as an OTC drug, has been widely used and still the incidence of agranulocytosis in these countries is casuistic. According to some Polish studies, the incidence of aplastic anaemia in the general population is incidental
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Цитата:
The recent analyses demonstrate that earlier findings concerning the incidence of metamizol-induced agranulocytosis and aplastic anaemia, which led to the ban of metamizol in many countries, were overestimated. Although metamizol is considered the drug potentially inducing agranulocytosis, the estimated risk of this complication shows high geographic variability, which is likely to reflect genetic differences of the populations assessed in epidemiological studies. Hedenmalm and Spigset
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В той же Германии, Анальгин не только не запрещен, но и продолжает фигурировать в исследованиях
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Стоит ли применять в качестве антипиретика, особенно у детей - не знаю.
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