reduction of raised intracranial pressure if ventilation controlled
•Raised intracranial pressure, by slow intravenous injection, 1.5–3 mg/kg, repeated as required
Indications induction of general anaesthesia; anaesthesia of short duration; reduction of raised intracranial pressure if ventilation controlled; status epilepticus (see also section 4.8.2)
Cautions see notes above; cardiovascular disease; reconstituted solution is highly alkaline—extravasation causes tissue necrosis and severe pain; avoid intra-arterial injection; interactions: Appendix 1 (anaesthetics, general)
Contra-indications see notes above; acute porphyria (section 9.8.2); myotonic dystrophy
Hepatic impairment reduce induction dose in severe liver disease
Pregnancy depresses neonatal respiration if used during delivery; dose should not exceed 250 mg
Breast-feeding present in milk—manufacturer advises avoid
Side-effects hypotension, arrhythmias, myocardial depression, laryngeal spasm, cough, sneezing, hypersensitivity reactions, rash, injection-site reactions; excessive doses associated with hypothermia and profound cerebral impairment
Thiopental has the following interaction information:
Droperidol effects of thiopental enhanced by droperidol
Probenecid effects of thiopental possibly enhanced by probenecid
Sulphonamides effects of thiopental enhanced by sulphonamides
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